Uncategorized

Zhen Ma

Assistant Professor, Carol and Samuel Nappi Research Scholar
Department of Biomedical & Chemical Engineering
Address: 318 Bowne Hall
Phone: 315-443-
E-mail: Zhen Ma <mazhen2046@gmail.com>
Lab website: http://myheart.syr.edu

Research Topics:

Cardiac Tissue Engineering and Organ-on-Chip:My lab focuses on the establishment multi-scale, multiplexed and multicellular cardiac tissue model, while also allowed me to develop “biologist-friendly” tools and instruments to explore single cell biology and 3D cell biology. Through these tissue models, I will gain mechanistic insights of human heart development, cardiac disease progression, drug efficacy and toxicity, and cell therapy benefits and risks.

Stem Cell Engineering and Organoid Models:My lab designs the organoid platform to promote the self-organization of 3D tissue structure to mimic early organ formation; to provide biophysical cues to drive the establishment of cell polarity for spatial tissue pattern; and to reduce tissue heterogeneity to create a systematic and experimentally reproducible in vitro organogenesis model.

 

 

Cell-Environment Interactions and Mechanobiology:
My lab utilizes engineering tools to precisely control the cellular microenvironment, to better analyze the cells’ responsiveness to external perturbations and delineate the signaling pathways underlying the observations.

Recent Publications:

      1. Mathur A., Ma Z., Loskill P., Jeeawoody S., and Healy K.E. (2016) “In vitro cardiac tissue models: current status and future prospects” Advanced Drug Delivery Reviews 96:203-13.
      2. Ma Z., Wang J., Loskill P., Huebsch N., Koo S., Svedlund F.L., Marks N.C., Hua E., Grigoropoulos C.P., Conklin B.R., and Healy K.E. (2015) “Self-organizing cardiac microchamber mediated by geometric confinement” Nature Communications 6: 7413.
      3. Ma Z., Koo S., Finnegan M.A., Loskill P., Huebsch N., Marks N.C., Grigoropoulos C.P., Conklin B.R., and Healy K.E. (2014) “Three-dimensional filamentous human diseased cardiac tissue model” Biomaterials 35(5): 1367-77.
      4. Ma Z., Liu Q., Yang H., Runyan R.B., Eisenberg C.A., Xu M., Borg T.K., Wang Y., and Gao B.Z. (2013) “Laser patterning for MSC cardiogenic differentiation study at the single-cell level” Light: Science and Application 2: e68.
    5. Ma Z., Liu Q., Liu H., Yang H., Yun J.X., Eisenberg C.A., Borg T.K., and Gao B.Z. (2012) “Laser-patterned stem-cell bridges in a cardiac muscle model for on-chip electrical conductivity analyses” Lab on a Chip 12(3): 566-73. Cover Article

Archive 2015 REU

REU Faculty, Students and Mentors

Welcome to the Interactive Biomaterials REU Program

May 31, 2015 – August 7, 2015
Syracuse Biomaterials Institute
Syracuse University – Syracuse, New York

Faculty located on the campuses of Syracuse University, SUNY ESF and SUNY Upstate Medical University.

APPLICATION, LETTERS OF RECOMMENDATION AND TRANSCRIPT MUST BE RECEIVED BY February 15, 2015

Program Highlights

Eligibility: Undergraduate students majoring in the following disciplines: Engineering, Chemistry, Biology or Physics with an interest in Biomaterials Science. Most Students will have completed their junior year, although talented students with less experience will be considered for acceptance in the program. Students must be U.S. Citizen or Permanent Resident.

Stipend: All participants will receive a stipend of $5400 and on-campus housing at no additional expense.

Possible Research Areas: Students have the opportunity to do research in any of the following areas:

  • Understanding bacteria-material interactions by surface engineering
  • Functionalization of biomimetic interfaces via engineered proteins
  • Control of Natural Polymers for Drug Delivery
  • 2D and 3D Active Cell Culture
  • Neurite Outgrowth on Substrates with Modulus Gradients
  • Smart Drug Release: Furanone Release from a Shape Memory Hydrogel
  • Designing Anticancer Drug Delivery and Gene Therapeutic Nanocarriers
  • Mechanism of Antimicrobial Peptide Action on Bacterial Cells
  • 3D Bioprinting

We are no longer accepting applications:

  • Complete the application form, which can either be completed online, or you can download, print, and mail in a hard copy.
  • The application includes a personal statement (one page) describing your career goals in scientific research and why you wish to participate in this program. For the online version, you may find it easier to compose the personal statement by using a word processor, and then copy/paste it into the form.

Online: Print a copy of the online form for your records, check the box indicating that you agree to the stated conditions, and submit the form.
or
Hard Copy: Make a copy of the form for your records, sign the bottom indicating that you agree to the stated conditions, and send the form to our mailing address, or PDF and email a copy to kplow@syr.edu

Transcript(s)
Only official university transcript will be accepted. Please mail transcript to REU Program Director, Jay Henderson, C/O Syracuse Biomaterials Institute, 318 Bowne Hall, Syracuse, NY 13244-1200

Letters of Recommendation:
Obtain two letters of recommendation from faculty members at your institution or elsewhere. These persons should be familiar with your academic and/or research abilities and should be able to judge whether you are suited for undergraduate research. Please contact your references prior to submitting your application. References may send their letters of recommendation (hard copy) directly to Jay Henderson or can email a PDF letter to Karen Low (kplow@syr.edu)

 

 

Interactive Biomaterials REU Program

2016 Program Announcement
June 5, 2016 – August 12, 2016

REU Students, Faculty and Mentors

SYRACUSE BIOMATERIALS INSTITUTE
318 Bowne Hall
Syracuse University
Syracuse, New York, 13214

APPLICATION, LETTERS OF RECOMMENDATION AND TRANSCRIPT MUST BE RECEIVED BY February 1, 2016

Program Highlights:

  • Collaborative research on the campuses of Syracuse University, Upstate Medical University and SUNY ESF
  • State-of-the-art research facilities
  • Seminars, workshops and field trips
  • REU Research Poster Session (students may be nominated to participate in NSF REU Symposium)

Eligibility:

  • Undergraduate students majoring in science or engineering*
  • U.S. Citizen or permanent resident
  • Minorities and women strongly encouraged to apply

*Most Students will have completed their junior year, although talented students with less experience will be considered for acceptance in the program.

Award:

  • $5800 Stipend
  • University Housing
  • $200 SUperCard to use in campus dinning and snack shops

Research Areas:

  • 3D Biofabrication/Bioprinting
  • Functional and Responsive Materials
  • Tissue engineering
  • Polymer Chemistry
  • Theory and Modeling
  • Mechanobiology
  • Polymer Rheology and Processing
  • Metals
  • Hydrogels
  • Biomaterial Composites
  • Theoretical Condensed Matter
  • Medical Devices

How to Apply

Click here to apply

  • Complete the application form, which can either be completed online, or you can download, print, and mail in a hard copy.
  • The application includes a personal statement (one page) describing your career goals in scientific research and why you wish to participate in this program. For the online version, you may find it easier to compose the personal statement by using a word processor, and then copy/paste it into the form.

Online: Print a copy of the online form for your records, check the box indicating that you agree to the stated conditions, and submit the form.
or
Hard Copy: Make a copy of the form for your records, sign the bottom indicating that you agree to the stated conditions, and send the form to our mailing address, or PDF and email a copy to kplow@syr.edu

Transcript(s):
Only official university transcript will be accepted. Please mail transcript to REU Program Director, Jay Henderson, C/O Syracuse Biomaterials Institute, 318 Bowne Hall, Syracuse, NY 13244-1200.

Letters of Recommendation:
Obtain two letters of recommendation from faculty members at your institution or elsewhere. These persons should be familiar with your academic and/or research abilities and should be able to judge whether you are suited for undergraduate research. Please contact your references prior to submitting your application. References may send their letters of recommendation (hard copy) directly to Jay Henderson or can email a PDF letter to Karen Low (kplow@syr.edu)

Interactive Biomaterials REU Program-test

2016 Program Announcement
June 5, 2016 – August 12, 2016

REU Students, Faculty and Mentors

SYRACUSE BIOMATERIALS INSTITUTE
318 Bowne Hall
Syracuse University
Syracuse, New York, 13214 

APPLICATION, LETTERS OF RECOMMENDATION AND TRANSCRIPT MUST BE RECEIVED BY February 1, 2016

Program Highlights:

  • Collaborative research on the campuses of Syracuse University, Upstate Medical University and SUNY ESF
  • State-of-the-art research facilities
  • Seminars, workshops and field trips
  • REU Research Poster Session (students may be nominated to participate in NSF REU Symposium)

Eligibility:

  • Undergraduate students majoring in science or engineering*
  • U.S. Citizen or permanent resident
  • Minorities and women strongly encouraged to apply

*Most Students will have completed their junior year, although talented students with less experience will be considered for acceptance in the program.

Award:

  • $5800 Stipend
  • University Housing
  • $200 SUperCard to use in campus dinning and snack shops

Research Areas:

  • 3D Biofabrication/Bioprinting
  • Functional and Responsive Materials
  • Tissue engineering
  • Polymer Chemistry
  • Theory and Modeling
  • Mechanobiology
  • Polymer Rheology and Processing
  • Metals
  • Hydrogels
  • Biomaterial Composites
  • Theoretical Condensed Matter
  • Medical Devices

How to Apply

Click here to apply

  • Complete the application form, which can either be completed online, or you can download, print, and mail in a hard copy.
  • The application includes a personal statement (one page) describing your career goals in scientific research and why you wish to participate in this program. For the online version, you may find it easier to compose the personal statement by using a word processor, and then copy/paste it into the form.

Online: Print a copy of the online form for your records, check the box indicating that you agree to the stated conditions, and submit the form.
or
Hard Copy: Make a copy of the form for your records, sign the bottom indicating that you agree to the stated conditions, and send the form to our mailing address, or PDF and email a copy to kplow@syr.edu

Transcript(s):
Only official university transcript will be accepted. Please mail transcript to REU Program Director, Jay Henderson, C/O Syracuse Biomaterials Institute, 318 Bowne Hall, Syracuse, NY 13244-1200. 

Letters of Recommendation:
Obtain two letters of recommendation from faculty members at your institution or elsewhere. These persons should be familiar with your academic and/or research abilities and should be able to judge whether you are suited for undergraduate research. Please contact your references prior to submitting your application. References may send their letters of recommendation (hard copy) directly to Jay Henderson or can email a PDF letter to Karen Low (kplow@syr.edu)

2013 HALLOWEEN BASH LUNCH

Costume Winners!

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Funniest: David Wilson (as Professor Henderson)
Professor Henderson  (as Otto the Orange Pumpkin!)

 

image006

Most Orignial: Kate Garrison 

image008
Best Costume:  Richard Baker

More:
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SBI Rooms

Item Location Contact
Modulated DSC with refrigerated cooling
TA Instruments Q100 DSC		 Bowne 4th floor Prof. Patrick Mather
Thermogravimetric Analysis
TA Instruments Q500		  Bowne 4th floor Prof. Patrick Mather
Rheometer
Anton Paar MCR501		 Bowne 4th floor  Prof. Patrick Mather
Quartz Crystal Microbalance
SRS QCM200		  Bowne 4th floor Prof. Patrick Mather
Polarizing Microscope with optical microrheometer, heating/cooling stage, shear cell, spectrographic birefringence apparatus, and Mito CCD attachments
Olympus BX-51		 Bowne 4th floor  Prof. Patrick Mather
Electrospinning apparatus
Custom Built		 Bowne 4th floor Prof. Patrick Mather
Incubator Shakers
New Brunswick C24		 Bowne 4th floor Prof. Patrick Mather
E-beam Evaporator (Ti, Au only)
Thermionics VE-100		  CST 3-036 Prof. Yan-Yeung Luk
Ellipsometer(discrete wavelength ellipsometer room) CST 4-041 Prof. Yan-Yeung Luk
Water Purification System
Millipore RiOs 5 and Milli-Q Biocel A-10		  CST 4-041 Prof. Yan-Yeung Luk
Polarizing Microscope
Olympus BX-51		 CST 3-036 Prof. Yan-Yeung Luk
Potensiostat
Pine Model AFCBP1		  CST 3-036 Prof. Yan-Yeung Luk
Labconco purifier vertical clean bench
Laminar hood		 CST 3-036 Prof. Yan-Yeung Luk
Cryogenic Storage System
VWR CryoPro BR-1		 CST 3-036 Prof. Yan-Yeung Luk
Inverted Microscope
Motic AE-31		 CST 3-036 Prof. Yan-Yeung Luk
Scanning Electron Microscope with X-ray Spectrophotometer
Joel 5600		 Bowne 4th floor Prof. Patrick Mather
Atomic Force Microscope with Electrochemical Attachment and Nanoindentation Capabilityg Bowne 4th floor Prof. Jeremy Gilbert
Digital Instruments Nanoscope III  Bowne 4th floor Prof. Patrick Mather
Hydraulic testing apparatus with 8500-Plus panel control and computer-controlled custom data collection
Instron 1350		  Bowne 4th floor Prof. Patrick Mather
Fourier Transform Infrared Spectrometer with AutoImage FTIR Microscope
Perkin-Elmer Spectrum One		 Bowne 4th floor Prof. Jeremy Gilbert
Differential scanning calorimeter
Perkin-Elmer Pyris 1		  Bowne 4th floor Prof. Patrick Mather
Inverted Fluorescence Microscope and Imaging System
Zeiss Axiovert 40 CFL with Phase Contrast		 Bowne 4th floor Prof. Patrick Mather
Custom built indentation system for microindentation of soft, hydrated polymers and biological materials  Bowne 4th floor Prof. Jeremy Gilbert
Rotational Viscometer
Brookfield DV-E		  Bowne 4th floor Prof. Patrick Mather
MicroCT Scanner
Scanco 40		 SUNY Upstate Prof. Kenneth Mann
Biaxial Servohydraulic Mechanical Test Frame
MTS Bionix		  SUNY Upstate Prof. Kenneth Mann
Fatigue crack growth measurement equipment
Fractomat/KrakGage		 SUNY Upstate Prof. Kenneth Mann
Surface Profilometer
Mitutoyo 178-923		  SUNY Upstate Prof. Kenneth Mann
Viscometer with small sample adaptor
Brookfield		  SUNY Upstate Prof. Kenneth Mann
SUN and PC Workstations with FEA Modeling and Medical Imaging Software
PATRAN, MARC, NASTRAN and MIMICS		  SUNY Upstate Prof. Kenneth Mann
Digital Image Correlation System (2-D) with Spot RT Camera
RapidCorrelator		  SUNY Upstate Prof. Kenneth Mann
Florescence Microscope with Motorized Z-Drive and Deconvolution Software.
ZEISS AXIO IMAGER MOT M1		  445 Link Hall  Prof. Dacheng Ren
DNA and Protein Electrophoresis Systems  445 Link Hall  Prof. Dacheng Ren
Western Blot System  445 Link Hall  Prof. Dacheng Ren
Spectrophotometer
Gensys 5		  445 Link Hall  Prof. Dacheng Ren
Microplate reader
FLx800, Bio-Tek Instruments, Inc.		  445 Link Hall  Prof. Dacheng Ren
Microcentrifuge Machines
5415D & 5415R, Eppendorf		  445 Link Hall  Prof. Dacheng Ren
Micropulser Electroporator
FLx800, Bio-Tek Instruments, Inc.		  445 Link Hall  Prof. Dacheng Ren
Luminometer
20/20n, Turner Design		  445 Link Hall  Prof. Dacheng Ren
Biofilm Flow Chamber Systems  445 Link Hall  Prof. Dacheng Ren

David Marcus

David is currently a Managing Director of VIMAC Milestone Medica, LP, an early stage life science fund with VIMAC Ventures, LLC, a Boston based venture capital firm. The fund invests in the pharmaceutical, medical device and instrument sectors with start-up companies based on emerging technologies from leading academic institutions. At VIMAC, David participates in the formation and capitalization of companies, and working closely with the Fund’s portfolio companies, is involved in licensing transactions, collaborative research agreements and clinical trial activities.

Before joining VIMAC, David had over twenty-five years of business development and new venture experience including with Colgate-Palmolive in their corporate M&A group, as well as CFO of a Colgate subsidiary and Director of M&A, Industrial Products for Colgate’s billion dollar health care and industrial specialty subsidiary, The Kendall Company. At Kendall, David developed and implemented a strategic growth plan through acquisition, and later went on to start up and run an in-house industrial polymer membrane business, which he grew, spun off and successfully sold to a large multinational company. Most recently, before joining VIMAC, David was a General Partner with Wellfleet Investments in Boston, a private equity placement firm that developed a portfolio of emerging life science technologies from leading medical research institutions. While at Wellfleet, he also served as CEO of a medical clinic established by the firm based on an advanced gastrointestinal rehabilitation therapy developed at a Harvard teaching hospital.

David is a graduate of Syracuse University (’70, BA, Political Science) and is a member of the Board of Visitors for SU’s College of Arts and Sciences. He holds an MBA from Pace University. He lives in Newton, MA with his wife and two daughters.