James Henderson

Jay Henderson
Associate Professor,
Department of Biomedical and Chemical Engineering
Director, Bioengineering Graduate Program
Address: 318 Bowne Hall
Phone: 315-443-9739
E-mail: jhhender@syr.edu
Lab website: http://henderson.syr.edu

Research:

Developing smart materials for the study and application of cell mechanobiology
Our goal is to understand how biophysical stimuli (e.g., stresses and strains) regulate tissue development, maintenance, and disease progression and to use that understanding to develop biomimetic bench-top research platforms, biomedical devices, and tissue-engineering and regenerative medicine approaches. Current projects focus on the treatment of orthopaedic injuries and on cancer.

Developing Advanced Computational Tools to Enable the Study and Application of Cell Mechanobiology
Our goal is to integrate innovative computational (for example, cell tracking) and experimental (for example, cell imaging) approaches to enable the study of cells in increasingly advanced and physiologically relevant in vitro environments. Current projects focus on dense cells interacting with 2D or 3D shape-changing biomaterial substrates and scaffolds.

Modulating Chondrogenesis for Tissue Engineering Applications
We are determining whether, and to what extent, biomechanical, biochemical, and topographical signals can modulate phenotypic characteristics of chondrocytes. Our long-term objective is to contribute key understanding to the engineering of functional articular cartilage. Current projects focus on the effects of mechanobiological signals from smart materials and on hypoxic expansion of the preparation and biomechanical properties of engineering cartilage.

Recent Publications:

Buffington SL, Ali MM, *Paul JE, *Macios MM, Mather PT, and Henderson JH. Enzymatically triggered shape memory polymers. Acta Biomaterialia. 84:88–97, 2019. https://doi.org/10.1016/j.actbio.2018.11.031
Wang J, Brasch ME, Baker RM, Tseng L, *Peña AN, Henderson JH. Shape memory activation can affect cell seeding of shape memory polymer scaffolds designed for tissue engineering and regenerative medicine.  Journal of Materials Science: Materials in Medicine, 28 (10), 151, 2017. https://doi.org/10.1007/s10856-017-5962-z
Song F, Brasch ME, Wang H, Henderson JH, Sauer K, and Ren D. How bacteria respond to material stiffness during attachment: a role of Escherichia coli flagellar motility. ACS Applied Materials & Interfaces, 9 (27), 22176-22184, 2017. https://doi.org/10.1021/acsami.7b04757
Wang J, *Quach A, Brasch ME, Turner CE, and Henderson JH. On-command on/off switching of progenitor cell and cancer cell polarized motility and aligned morphology via a cytocompatible shape memory polymer scaffold. Biomaterials, 140: 150-61, 2017. https://doi.org/10.1016/j.biomaterials.2017.06.016
Gu H, Lee SW, Buffington SL, Henderson JH, and Ren D. On-demand removal of bacterial biofilms via shape memory activation. ACS Applied Materials & Interfaces, 8 (33), 21140-21144, 2016. https://doi.org/10.1021/acsami.6b06900
Tseng L, Wang J, Baker RM, Wang G, Mather PT, and Henderson JH. Osteogenic capacity of human adipose-derived stem cells is preserved following triggering of shape memory scaffolds. Tissue Engineering Part A. August, 22(15-16): 1026-1035, 2016. https://doi.org/10.1089/ten.tea.2016.0095
Gu H, Chen A, Song X, Brasch ME, Henderson JH, and Ren D. How Escherichia coli lands and forms cell clusters on a surface: a new role of surface topography. Scientific Reports, 6:29516, 2016. https://doi.org/10.1038/srep29516
Baker RM, Tseng L, Iannolo MT, Oest ME, and Henderson JH. Self-deploying shape memory polymer scaffolds for grafting and stabilizing complex bone defects: A mouse femoral segmental defect study. Biomaterials, 2016;76:388-98. https://doi.org/10.1016/j.biomaterials.2015.10.064
Baker RM, Brasch ME, Manning ML, and Henderson JH. Automated, contour-based tracking and analysis of cell behaviour over long timescales in environments of varying complexity and cell density. Journal of the Royal Society Interface, 11(97), 20140386, 2014. https://doi.org/10.1098/rsif.2014.0386
Program download at: http://henderson.syr.edu/downloads/
Wormer DB, Davis KA, Henderson JH, Turner CE. The focal adhesion-localized CdGAP regulates matrix rigidity sensing and durotaxis. PLoS ONE, 9(3): e91815, 2014. https://doi.org/10.1371/journal.pone.0091815
Tseng L, Mather PT, and Henderson JH. Shape-memory actuated change in scaffold fiber alignment directs stem cell morphology. Acta Biomaterialia, 9:8790-8801, 2013. https://doi.org/10.1016/j.actbio.2013.06.043
Baker RM, Henderson JH, and Mather PT. Shape memory poly(ε-caprolactone)-co-poly(ethylene glycol) foams with body temperature triggering and two-way actuation. Journal of Materials Chemistry B, 1:4916-4920, 2013. https://doi.org/10.1039/C3TB20810A
Baker RM, Yang P, Henderson JH, and Mather PT. In vitro wrinkle formation via shape memory dynamically aligns adherent cells. Soft Matter, 9:4705–4714, 2013. https://doi.org/10.1039/C3SM00024A
Xu X, Davis KA, Yang P, Gu X, Henderson JH, and Mather PT. Shape memory RGD-containing hydrogels: synthesis, characterization, and application in cell culture. Macromolecular Symposia, 309-310: 162-172, 2011. https://doi.org/10.1002/masy.201100060
Davis KA, Luo X, Mather PT, and Henderson JH. Shape memory polymers for active cell culture. J Vis Exp, (53):e2903, 2011. *Video article viewed more than 6,000 times. http://www.jove.com/details.php?ID=2903
Davis KA, Burke KA, Mather PT, and Henderson JH. Dynamic cell behavior on shape memory polymer substrates. Biomaterials, 32:2285–2293, 2011. https://doi.org/10.1016/J.Biomaterials.2010.12.006

 

 

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