Stevenson Biomaterials Lectures Series Presentation
Friday, April 11, 2008, 2 PM - 4 PM
500 Hall of Languages
PDF Invitation
With Guest Speaker
Lori A Setton, Ph.D.
Mary M. Yoh and Harold L. Yoh, Jr. Professor of Biomedical Engineering and Surgery
Duke University
"Rational Approach To The Design Of Hydrogels For Cartilage Repair"
Abstract:
Biomaterials to promote cartilage regeneration are attractive for their potential to promote functional restoration of the damaged tissue. Restoration of cartilage "function" is a poorly defined and challenging design goal, however, cartilage has important mechanical, biochemical, and biological behaviors that are difficult to simultaneously target with any one strategy. Our laboratory is developing novel uses of statistical models to optimize biomaterial features for a successful cartilage regeneration outcome. One biomaterial of interest is a hydrogel composed from elastin-like polypeptides (ELP). These ELPs are monodisperse and precisely controlled through genetic encoding of amino acid sequence, molecular weight, and sites for controlled crosslinking. This talk will describe our experience with a genetically-engineered polypeptide hydrogel for restoration of tissue function specific to articular cartilage.
Biography:
Dr. Setton received her B.S.E. from Princeton University in Mechanical and Aerospace Engineering, with M.S. and Ph.D. degrees in Mechanical Engineering from Columbia University. Dr. Setton joined the Department of Biomedical Engineering at Duke University in 1994, where she is currently the Yoh, Jr. Professor of Biomedical Engineering and Surgery.
Dr. Setton's research focuses on understanding the mechanisms for degeneration and regeneration of soft tissues of the musculoskeletal system. Recent work focuses on development of in situ forming hydrogels for drug delivery and regeneration. She has funded her lab through grants from the NIH, NSF, Whitaker Foundation, Coulter Foundation, OREF, and North Carolina Biotechnology Center.
Dr. Setton has over 85 peer-reviewed publications and holds several patents. She has served as Associate Editor for the Journal of Biomechanical Engineering and on the Editorial Advisory Boards of several other journals. She has also served as a permanent member of NIH and NSF study sections, a consultant to NIH and AAOS, and on the Boards of ORS, BMES, and World Council on Biomechanics. Dr. Setton is a Fellow of the AIMBE and has received a PECASE Award, Dean's Award for Outstanding Research, Graduate Dean's Award for Excellence in Mentoring, and ASME's Mow Medal.
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